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M. Cesen, T. Kosjek, M. Laimou-Geraniou, B. Kompare, B. Sirok, D. Lambropolou, E. Heath, Occurrence of cyclophosphamide and ifosfamide in aqueous environment and their removal by biological and abiotic wastewater, Science of the Total Environment, 527-528, 465-473, 2015.

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Article

Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide

1Ludwigsburg University of Education, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany

2University of Hildesheim, Hildesheim, Germany


Applied Ecology and Environmental Sciences. 2018, Vol. 6 No. 1, 15-22
DOI: 10.12691/aees-6-1-3
Copyright © 2018 Science and Education Publishing

Cite this paper:
C. Laauser, G. Habekost, A. Habekost. Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide. Applied Ecology and Environmental Sciences. 2018; 6(1):15-22. doi: 10.12691/aees-6-1-3.

Correspondence to: A.  Habekost, Ludwigsburg University of Education, Department of Chemistry, Reuteallee 46, D-71634 Ludwigsburg, Germany. Email: A.Habekost@t-online.de

Abstract

A flow tube reactor containing iron or zinc powder in a nitrogen atmosphere is capable of performing >90% anaerobic reductive dehalogenation of the cancer drugs ifosfamide and cyclophosphamide at 400 °C using toluene, alcohol or water as proton donors and iron or zinc as reducing agents. The products are all chlorine-free, as proven by GC-MS. The process is particularly interesting for large-scale industrial applications.

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