1Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
2Department of Otorhinolaryngology, the First Affiliated Hospital of Jiamushi University, Jiamushi, Heilongjiang Province, China
International Journal of Clinical and Experimental Neurology.
2013,
Vol. 1 No. 1, 5-11
DOI: 10.12691/ijcen-1-1-2
Copyright © 2013 Science and Education PublishingCite this paper: Yu Zhao, Shijun Wang. Neural Stem Cell Transplantation Inhibits Apoptosis through Activation of MAPK/ERK Signaling Pathway in Cerebral Ischemia/Reperfusion Rats.
International Journal of Clinical and Experimental Neurology. 2013; 1(1):5-11. doi: 10.12691/ijcen-1-1-2.
Correspondence to: Yu Zhao, Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Email:
zhaoyu0916@gmail.comAbstract
Apoptosis, a major pathogenesis of cerebral ischemia, is closely associated with the dysregulation of MAPK/ERK signaling pathway. The transplantation of neural stem cells (NSCs), as a therapeutic target of cerebral ischemia, could repair missing cells and the activation of endogenous cells to provide "self-repair". However, the neuroprotective mechanism of the transplantation of NSCs against cerebral ischemia injury is unclear. This study is to investigate the effect of the transplantation of NSCs on apoptosis and MAPK/ERK signaling in the cerebral ischemia/reperfusion rats to evaluate its neuroprotective role. These results suggest that the transplantation of NSCs provides a neuroprotective effect via decreasing neurological deficit and increasing the activity of MAPK/ERK signaling in MCAO-lesioned brains and restraining apoptosis. In view of the treatment and prevention of ischemic brain damage, the ability of NSCs to enhance the activity of MAPK/ERK signaling and inhibit apoptosis may be of great importance in the selection of neuroprotective agents.
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