1Laboratoire de Biochimie et de Microbiologie, Ecole Normale Supérieure de Natitingou, University of Parakou
American Journal of Biomedical Research.
2017,
Vol. 5 No. 2, 35-38
DOI: 10.12691/ajbr-5-2-3
Copyright © 2017 Science and Education PublishingCite this paper: Cyrille Alode VODOUNON. Abzymes in the Diagnosis of Bronchial Asthma.
American Journal of Biomedical Research. 2017; 5(2):35-38. doi: 10.12691/ajbr-5-2-3.
Correspondence to: Cyrille Alode VODOUNON, Laboratoire de Biochimie et de Microbiologie, Ecole Normale Supérieure de Natitingou, University of Parakou. Email:
sweetiebj@yahoo.frAbstract
The objective of the present work was to study the predominance of abzymes in the diagnosis of Bronchial Asthma. The study was carried out using the blood serum of several groups of patients, including patients with Bronchial Asthma (n=15), allergic Rhino-conjunctivitis (polypus)(n=15), Systemic Lupus Erythématosis(n=10) and Auto-Immune Thyroiditis (n=10). Detection of IgG auto-AB against DNA was carried out by Enzyme-linked immunosorbent assay (ELISA) and the catalytic activity of antibody against DNA was determined by electrophoresis method. The results of our study revealed abundant auto-antibodies to DNA in the blood vessels of the patients with bronchial asthma and there was a direct correlation dependence (r=0.0005) between the level of auto-antibodies to DNA and the severity of the disease. Circulating auto-antibodies in blood serum possess catalytic activity of DNA which is associated with the degree of severity of asthma. Thus, autoantibody can be used as serologic markers for the diagnosis of BA and can even be suitable, according to their concentration, for determining the degree of severity of the disease.
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