Article citationsMore >>

Casolaro MA, Bernaudin JF, Saltini C, Ferrans VJ, Crystal RG. Accumulation of Langerhans’cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking. Am Rev Respir Dis 1988;137:406-11.

has been cited by the following article:

Article

Histiocytosis with Pulmonary Involvement Mimicking Rheumatoid Arthritis

1Internal Medicine Department, University Hospital of Charles Nicolle, Tunis, Tunisia

2Rheumatology Department, University Hospital of Charles Nicolle, Tunis, Tunisia

3Department of Diagnostic Pathology, University Hospital of Charles Nicolle, Tunis, Tunisia


American Journal of Medical Case Reports. 2016, Vol. 4 No. 8, 293-295
DOI: 10.12691/ajmcr-4-8-9
Copyright © 2016 Science and Education Publishing

Cite this paper:
Imene Boukhris, Hana Zoubaidi, Ines kechaou, Eya Chérif, Ines mahmoud, Anis Hariz, Nédia Znaidi, Narjes Khalfallah. Histiocytosis with Pulmonary Involvement Mimicking Rheumatoid Arthritis. American Journal of Medical Case Reports. 2016; 4(8):293-295. doi: 10.12691/ajmcr-4-8-9.

Correspondence to: Imene  Boukhris, Internal Medicine Department, University Hospital of Charles Nicolle, Tunis, Tunisia. Email: imen.boukhris@laposte.net

Abstract

In Langerhans cell histiocytosis pulmonary involvement is often isolated. It is rarely a part of a multifocal form. Tenosynovitis is exceptional. Hand bones involvement is atypical. We report the case of a 75-year-old, non-smoker man, without medical history, who presented with arthritis and fever. Examination found arthritis affecting large and small joints. In biology, there was an inflammatory syndrome. Radiographs of the hands showed erosions of the carpal bones. Doppler ultrasonography of the hands showed active synovitis. Tc99 bone scintigraphy highlighted joint uptake in the hands, knees, spine and right upper jaw. Blood cultures and infectious investigations were negative. Anti-nuclear antibodies and rheumatoid factor were negatives. CT scan showed cystic lung lesions and nodular aspect. Bronchoalveolar lavage fluid revealed positivity of anti-CD1a at 6%. A surgical biopsy showed an infiltrate of eosinophilic cells, positive for CD1a in immunohistochemistry studies. The diagnosis of Langerhans cell histiocytosis was retained.

Keywords