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Shortt J, Johnstone RW. Oncogenes in Cell Survival and Cell Death. Cold Spring Harb Perspect Biol 2012; 4: a009829.

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Article

Apoptosis: Insights into Pathways and Role of p53, Bcl-2 and Sphingosine Kinases

1Pharmacology department, Faculty of Medicine, Tanta University, Egypt

2Clinical Pharmacy department, College of Pharmacy, Taif University, Taif, KSA

3Pharmacology department, Faculty of Medicine, Zawia University, Lybia

4Pharmacology and toxicology department, Faculty of Pharmacy, Helwan University, Egypt


Journal of Cancer Research and Treatment. 2016, Vol. 4 No. 4, 69-72
DOI: 10.12691/jcrt-4-4-3
Copyright © 2016 Science and Education Publishing

Cite this paper:
Ahmed M. Kabel, Almokhtar A. Adwas, Abeer A. Elkhoely, Mohamed Nabih Abdel-Rahman, Amany A. Eissa. Apoptosis: Insights into Pathways and Role of p53, Bcl-2 and Sphingosine Kinases. Journal of Cancer Research and Treatment. 2016; 4(4):69-72. doi: 10.12691/jcrt-4-4-3.

Correspondence to: Ahmed  M. Kabel, Pharmacology department, Faculty of Medicine, Tanta University, Egypt. Email: drakabel@gmail.com

Abstract

Apoptosis or programmed cell death is characterized by certain morphological and biochemical characteristics. It is a vital process for normal cell turnover, proper development and functioning of the immune system, embryonic development and chemical-induced cell death. Disturbances of apoptosis play a key role in many diseases including neurodegenerative diseases, autoimmune disorders and many types of cancer. The field of apoptosis research has been moving forward at a rapid rate. Although many of the key proteins that play a role in apoptosis have been identified, the molecular mechanisms of action of these proteins had not been fully elucidated. The aim of this mini-review is to provide a general overview on the process of apoptosis including pathways, regulation, the role of apoptosis in health and disease as well as the role of p53, Bcl-2 and sphingosine kinase-1 in apoptosis.

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