1B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
2AESKU.KIPP Institute, Wendelsheim, Germany
International Journal of Celiac Disease.
2016,
Vol. 4 No. 2, 68-70
DOI: 10.12691/ijcd-4-2-1
Copyright © 2016 Science and Education PublishingCite this paper: Aaron Lerner, Sandra Neidhöfer, Torsten Matthias. The Gut-gut Axis: Cohabitation of Celiac, Crohn’s Disease and IgA Deficiency.
International Journal of Celiac Disease. 2016; 4(2):68-70. doi: 10.12691/ijcd-4-2-1.
Correspondence to: Aaron Lerner, B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Email:
aaronlerner1948@gmail.comAbstract
An adult patient with IgA deficiency, celiac and Crohn’s disease is described. In addition to the rare association, he developed an unusual proximal Crohn’s disease. Unbalanced microbiome, increased intestinal permeability, susceptibility to infections that might initiate post translational modification of naïve protein and the genetic background, are shared between the three entities. It is speculated that the IgA immune deficiency and its consequences are the early factors that set the stage for the progression of the other two diseases. Based on recent knowledge, special nutritional therapies should be considered, in addition to the gluten free diet.
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