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Chen, W., et al., Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 2003. 198(12): p. 1875-86.

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Article

The Effect of Giving Trigona Honey and Honey Propolis Trigona to the mRNA Foxp3 Expression in Mice Balb/c Strain Induced by Salmonella Typhi

1Department of Epidemiology, Health College of RSU Daya, Makassar, Indonesia

2Department of Nursing, Hasanuddin University, Makassar, Indonesia

3Department of Biochemistry, Hasanuddin University, Makassar, Indonesia

4Department of ENT, Faculty of Medicine, Hasanuddin University, Indonesia

5Department Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

6Department of Microbiology, Tadulako University, Palu, Indonesia

7Department of Clinical Pathology, Hasanuddin University, Makassar, Indonesia

8Department of Chemistry, Hasanuddin University, Makassar, Indonesia

9Department of Oncology, Hasanuddin University, Makassar, Indonesia


American Journal of Biomedical Research. 2016, Vol. 4 No. 2, 42-45
DOI: 10.12691/ajbr-4-2-3
Copyright © 2016 Science and Education Publishing

Cite this paper:
Andi Nilawati Usman, Yuliana Syam, Rosdiana Natzir, Sutji Pratiwi Rahardjo, Mochammad Hatta, Ressy Dwiyanti, Yuyun Widaningsih, Ainurafiq, Prihantono. The Effect of Giving Trigona Honey and Honey Propolis Trigona to the mRNA Foxp3 Expression in Mice Balb/c Strain Induced by Salmonella Typhi. American Journal of Biomedical Research. 2016; 4(2):42-45. doi: 10.12691/ajbr-4-2-3.

Correspondence to: Mochammad  Hatta, Department Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Email: hattaram@indosat.net.id

Abstract

Immune balance during infection is important to support both the defense of body immune system and prevent excessive immune response. Protein Foxp3, a transcription factor of regulatory T cell has pivotal roles in balancing body immune system. Honey and Propolis have proved their effects to both the proinflamatory and anti inflammatory responses but their effects to the Foxp3 expression need to be investigated. This study was investigated the effect of giving Trigona honey and honey propolis Trigona to the mRNA Foxp3 expression in Balb/c mice induced Salmonella typhi. Results of the study indicated that honey propolis Trigona had the highest effect to the mRNA Foxp3 expression followed by Trigona honey. Both Trigona honey and honey propolis had immunomodulatory effects through the Foxp3 mRNA expression.

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