1Department of General Surgery, Hospital of traditional Chinese medicine of Yubei, Chongqing, 400010, China
2Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China
3Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China
American Journal of Cancer Prevention.
2016,
Vol. 4 No. 1, 18-22
DOI: 10.12691/ajcp-4-1-4
Copyright © 2016 Science and Education PublishingCite this paper: Wei Chen, Xiaoli Yang, Yakun Wu. The Effect of Local Regional Therapy on Post-transplantation Survival Rate in Patients with Hepatocellular Carcinoma.
American Journal of Cancer Prevention. 2016; 4(1):18-22. doi: 10.12691/ajcp-4-1-4.
Correspondence to: Yakun Wu, Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China. Email:
353827514@qq.comlAbstract
Background and Objective: This study aims to use meta-analysis to evaluate whether pre-transplantation local regional therapy (LRT) can improve the survival of patients with hepatocellular carcinoma who accepted liver transplantation. Methods: Relevant studies were identified by searching PUBMED, EMBASE and Web of Science Datebases up to May 2015. Endpoints were 1 year, 3 years, and 5 years survival rate after liver transplantation. Results: Analysis of nine retrospective studies including 1097 patients did not reveal significant difference in 1year, 3 years and 5 years survival rate between the patients who got LRT or not. Analysis of four retrospective studies including 504 patients showed patients with complete response to LRT have higher 5 years survival rate. Conclusions: The results of this meta-analysis suggest that the patients with complete response to LRT have higher post-transplantation survival rate. But LRT before liver transplantation can’t improve the overall survival rate.
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