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Maluf DG, Stravitz RT, Williams B, Cotterell AH, Mas VR, Heuman D, Luketic V, Shiffman ML, Sterling R, Posner MP, Fisher RA, “Multimodality therapy and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: 6 years, single-center experience”, Transplant Proc, 39(1):153-9, Jan-Feb 2007.

has been cited by the following article:

Article

The Effect of Local Regional Therapy on Post-transplantation Survival Rate in Patients with Hepatocellular Carcinoma

1Department of General Surgery, Hospital of traditional Chinese medicine of Yubei, Chongqing, 400010, China

2Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China

3Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China


American Journal of Cancer Prevention. 2016, Vol. 4 No. 1, 18-22
DOI: 10.12691/ajcp-4-1-4
Copyright © 2016 Science and Education Publishing

Cite this paper:
Wei Chen, Xiaoli Yang, Yakun Wu. The Effect of Local Regional Therapy on Post-transplantation Survival Rate in Patients with Hepatocellular Carcinoma. American Journal of Cancer Prevention. 2016; 4(1):18-22. doi: 10.12691/ajcp-4-1-4.

Correspondence to: Yakun  Wu, Department of Hepatobiliary Surgery, Suining Central Hospital, Suining 629000, China. Email: 353827514@qq.coml

Abstract

Background and Objective: This study aims to use meta-analysis to evaluate whether pre-transplantation local regional therapy (LRT) can improve the survival of patients with hepatocellular carcinoma who accepted liver transplantation. Methods: Relevant studies were identified by searching PUBMED, EMBASE and Web of Science Datebases up to May 2015. Endpoints were 1 year, 3 years, and 5 years survival rate after liver transplantation. Results: Analysis of nine retrospective studies including 1097 patients did not reveal significant difference in 1year, 3 years and 5 years survival rate between the patients who got LRT or not. Analysis of four retrospective studies including 504 patients showed patients with complete response to LRT have higher 5 years survival rate. Conclusions: The results of this meta-analysis suggest that the patients with complete response to LRT have higher post-transplantation survival rate. But LRT before liver transplantation can’t improve the overall survival rate.

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