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Deshpande SD, Koppikar GV. A study of mycotic Keratitis in Mumbai. Indian J. Pathol. Microbiot 1999; 42(1): 81-87.

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Article

Keratomycosis: Some Epidemiological Data, Diagnosis and Drug Sensitivity

1Pathology and Microbiology Unit, Department of Para- Clinical Sciences, University of West Indies, St. Augustine, Trinidad and Tobago

2Department of Microbiology, Government Medical College and Hospital, Nagpur, India

3Physiology Unit, Department of Preclinical Sciences, University of West Indies, St. Augustine. Trinidad and Tobago

4Great Eastern Medical School, Srikakulum, India

5Department of Pediatrics, JNMC, Dutta Meghe University of Medical Sciences, Sawngi, Wardha, India

6Defense Services Staff College, Madras University, Wellington, India


American Journal of Infectious Diseases and Microbiology. 2016, Vol. 4 No. 1, 22-24
DOI: 10.12691/ajidm-4-1-4
Copyright © 2016 Science and Education Publishing

Cite this paper:
Arvind M. Kurhade, Meena Mishra, Geeta Kurhade, Angel Justiz Vaillant, Sudhir Lakhdive, Krutika Kurhade, Tejaswini H. Joshi, Sehlule Vuma. Keratomycosis: Some Epidemiological Data, Diagnosis and Drug Sensitivity. American Journal of Infectious Diseases and Microbiology. 2016; 4(1):22-24. doi: 10.12691/ajidm-4-1-4.

Correspondence to: Angel  Justiz Vaillant, Pathology and Microbiology Unit, Department of Para- Clinical Sciences, University of West Indies, St. Augustine, Trinidad and Tobago. Email: Angel.Vaillant@sta.uwi.edu

Abstract

Purpose: The present study was undertaken to investigate the prevalence of mycotic keratitis and the profile of the fungi responsible in this region. Special attention was given to assess the prevalence of various species of Aspergillus, predisposing factors for keratomycosis and drug sensitivity. Methods: Corneal scraping samples from 148 cases of corneal ulcer and traumatic corneal infection with clinically suspicion of having fungal infections were examined microscopically and for culture. Minimum inhibitory concentration (MIC) of itraconazole and amphotericin-B were tested against the Aspergillus species isolates. Results: Aspergillus species were isolated in 26 (20.15%) cases and Aspergillus fumigatus was the predominant species isolated in 17 (65.38%) cases. This fungus was found to be sensitive to itraconazole with MIC of 0,125 -1 µg/ml. Conclusion: Aspergillus fumigatus is more common in mycotic keratitis, and itraconazole is effective against it. Vegetative trauma is the major risk factor.

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