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Brock I, Latent Tuberculosis in HIV positive, diagnosed by the M. Tuberculosis Specific Interferon-γ test. Respiratory Research 2006; 7(56).

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Article

What is the Rate of Latent Tuberculosis Infection in Human Immunodeficiency Virus (HIV) Infected Patients in Saudi Arabia?

1Department of Medicine, Division of Infectious Diseases, National Guard Health Affairs, Riyadh, Saudi Arabia

2Department of Medicine, Divsion of Infectious Diseases, King Abdulaziz Medical City, Riyadh, Saudi Arabia

3Department of Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia


American Journal of Epidemiology and Infectious Disease. 2016, Vol. 4 No. 1, 10-13
DOI: 10.12691/ajeid-4-1-2
Copyright © 2016 Science and Education Publishing

Cite this paper:
Hythum Salah H. Mohamed, Adel Alothman, Henry Baffoe-Bonnie, Hisham Alageeb. What is the Rate of Latent Tuberculosis Infection in Human Immunodeficiency Virus (HIV) Infected Patients in Saudi Arabia?. American Journal of Epidemiology and Infectious Disease. 2016; 4(1):10-13. doi: 10.12691/ajeid-4-1-2.

Correspondence to: Hythum  Salah H. Mohamed, Department of Medicine, Division of Infectious Diseases, National Guard Health Affairs, Riyadh, Saudi Arabia. Email: alnoby90@gmail.com

Abstract

Background/Objectives: Despite significant investments in Tuberculosis (TB) control over 15 years, TB remains an important public health problem in Saudi Arabia (SA) affecting all age groups, and on the other side there is a notable increased in the number of people living with Human Immunodeficiency virus (HIV) in SA. This study was designed to estimate the prevalence of Latent Tuberculosis Infection (LTBI) among HIV-infected patients in a tertiary care hospital in Saudi Arabia (SA.Our study is the first study in the Middle East up to our knowledge and literature review in HIV-infected subjects. Material/methods: Retrospective study was conducted with a total of 61 HIV seropositive patients attended and followed up at data was collected and recorded form patients’ charts, electronic health record system and HIV data base for age, gender, nationality, chest- XR and CD4 count and also for Quantiferon test (QFT) which was used as screening test for detection of LTBI. Results: Among our patients, 46 were male (75.4 %) and 15 were female (24.6 %), the mean age was 44.4 years (age range 19-77 years), 57 were Saudi (93.4%) and 4 were non- Saudi (6.6 %). The mean baseline CD4 count for all patients was 285 cells/mm3. QFT was done for 40 patients (66.7%), 2/40 patients were positive (5.0 %), 35/40 patients were negative (87.5%) and 3/40 patients were intermediate (7.5%). Conclusions: We found an overall prevalence of LTBI is 5 % among HIV-infected individuals in SA, which is relatively low especially in TB endemic country, more epidemiological studies are needed in this high-risk group of patients for latent Tuberculosis in SA.

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