1Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics, v.v.i., Libechov, Czech Republic
2Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic
3Department of Surgery, 1st Medical Faculty, Charles University and Hospital Na Bulovce, Prague, Czech Republic
International Journal of Celiac Disease.
2015,
Vol. 3 No. 4, 148-150
DOI: 10.12691/ijcd-3-4-6
Copyright © 2015 Science and Education PublishingCite this paper: Jana Cizkova, Monika Cervinkova. Celiac Disease and Cancer – Are There Potential Links? Is the Vigilance of Immune System in Celiac Disease a Double-edged Sword?.
International Journal of Celiac Disease. 2015; 3(4):148-150. doi: 10.12691/ijcd-3-4-6.
Correspondence to: Monika Cervinkova, Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics, v.v.i., Libechov, Czech Republic. Email:
cervinkova@iapg.cas.czAbstract
Celiac disease (CD) is a chronic immune – mediated inflammatory intestinal disorder with prevalence about 1% of the West European population. The emergence of the disease is dependent on presence of grain storage proteins from wheat, barley, and rye (collectively called gluten) and genetic predisposition. After diagnosis is immediately deployed lifelong gluten free diet (GFD) to promote villous healing. In the case of CD - like other autoimmune disease, additional complications are observed especially if dietary compliance is poor. The most serious complications are malignancies including predominantly various types of lymphomas. On the other hand recent studies indicate lower risk of colon cancer in contrast to cutaneous malignant melanoma where the results are contradictory.
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