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Koroglu M, Erkurt MA, Berber I, Kuku I, Kaya E, Ozkahraman A, Aydin NE. Primarily unknown origin adenocarcinoma metastasis in bone marrow presenting with thrombotic thrombocytopenic purpura: a case report. Transfus Apher Sci. 2013 Oct; 49(2): 341-4.

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Article

Carcinoma Causing Thrombotic Thrombocytopenic Purpura and Myelonecrosis: A Very Rare Event

1Hematology Department, Inonu University Turgut Ozal Medical Center, Malatya, Turkey

2Karabuk University Karabuk Education and Research Hospital, Karabuk, Turkey

3Pathology Department, Inonu University Turgut Ozal Medical Center, Malatya, Turkey


American Journal of Medical Case Reports. 2015, Vol. 3 No. 11, 372-373
DOI: 10.12691/ajmcr-3-11-6
Copyright © 2015 Science and Education Publishing

Cite this paper:
Ilknur Nizam, Mehmet Ali Erkurt, Ilhami Berber, Mustafa Koroglu, Emin Kaya, Irfan Kuku, Nese Karadag. Carcinoma Causing Thrombotic Thrombocytopenic Purpura and Myelonecrosis: A Very Rare Event. American Journal of Medical Case Reports. 2015; 3(11):372-373. doi: 10.12691/ajmcr-3-11-6.

Abstract

We report a case of thrombotic thrombocytopenic purpura (TTP) which was explored to be the clinical presentation of carcinoma. Plasma exchange therapy failed to respond for the patient, so bone marrow aspiration and biopsy were performed to find out the reason of microangiopathic hemolytic anemia. Bone marrow examination revealed non hematopoetic cell infiltration and myelonecrosis. Carcinoma metastasis was demonstrated at bone marrow trephine biopsy. The primary tumor was found at small bowel after scanning for the source of tumor by computerized tomography.

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