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K. Lugo, X. Miao, F. Rieke, and L. Y. Lin, Remote switching of cellular activity and cell signaling using light in conjunction with quantum dots, Biomed Opt Express, vol. 3, pp. 447-54, Mar 1 2012.

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Article

Challenges and Advances in Near Infrared Spectroscopy for Evaluating Hemodynamics in Brain

1Department of Systems Life Engineering, Maebashi Institute of Technology, Kamisadori, Maebashi, Japan


Biomedical Science and Engineering. 2015, Vol. 3 No. 2, 35-40
DOI: 10.12691/bse-3-2-2
Copyright © 2015 Science and Education Publishing

Cite this paper:
Yasutomo Nomura. Challenges and Advances in Near Infrared Spectroscopy for Evaluating Hemodynamics in Brain. Biomedical Science and Engineering. 2015; 3(2):35-40. doi: 10.12691/bse-3-2-2.

Correspondence to: Yasutomo  Nomura, Department of Systems Life Engineering, Maebashi Institute of Technology, Kamisadori, Maebashi, Japan. Email: ynomura@maebashi-it.ac.jp

Abstract

Near infrared spectroscopy is a powerful technique to evaluate hemodynamics in cerebral tissue where the light used is subject to the low scattering effect. In this wavelength range, hemoglobin has the characteristic absorption spectra. Because of the noninvasive method, this gives valuable information containing venous blood to the clinical field such as cardiac surgery, neurosurgery and pediatrics. Although the technique originates from classical biochemistry with clear solution, researchers have proposed creative ideas to be suitable for measuring hemodynamics in living tissue optically. In this mini-review, theoretical basis from Lambert-Beer law to multiwavelength method and derivation of the linear relationship between absorption and concentration of pigments from the time-resolved method are described. Furthermore the recent advances are also outlined.

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