1Rasool-Akram Hospital, Oncology and Hematology ward, Iran University of Medical Sciences, Tehran, Iran
2Department of Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
American Journal of Cancer Prevention.
2015,
Vol. 3 No. 5, 91-93
DOI: 10.12691/ajcp-3-5-4
Copyright © 2015 Science and Education PublishingCite this paper: Ali Shahriari-Ahmadi, Babak Izadi, Masoud Sadeghi, Mehrdad Payandeh, Edris Sadeghi. Epstein-Barr virus and non-Hodgkin lymphoma: A study in Kermanshah, Iran.
American Journal of Cancer Prevention. 2015; 3(5):91-93. doi: 10.12691/ajcp-3-5-4.
Correspondence to: Masoud Sadeghi, Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:
Sadeghi_mbrc@yahoo.comAbstract
Background: Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma such as types of aggressive non-Hodgkin lymphoma (NHL). We aimed to evaluate the prevalence of EBV in NHL and its association with clinical parameters. Patients and Methods: twenty cases entered to our study. After re-blocking of previous paraffin embedded specimens, new slides were prepared and DNA was extracted. DNA contents were confirmed by spectrophotometery. Then PCR assay was used for total DNA and its product evaluate for presence of EBV by electrophoresis. Results: The mean age at diagnosis for all patients was 45±13 years (range, 28-73) years that 12 patients (60%) were male. Based on histopathology reports, 13 patients (65%) had immunoblastic Lymphoma, 5 (25%) had burkitt Lymphoma and 2 (10%) had LL (lymphoblastic Lymphoma). Conclusion: There is no EBV infection in NHL patients with LLs and percent of EBV infection in our study is lower than other studies.
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