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Palladini G, Russo P, Bosoni T, Sarais G, Lavatelli F, Foli A, et al. AL amyloidosis associated with IgM monoclonal protein: a distinct clinical entity. Clin Lymphoma Myeloma 2009;9: 80-3.

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Article

Exceptional Cause of Massive Lymph Node Enlargement: Primary Localized Amyloidosis

1Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

2Department of Diagnostic Pathology, University hospital of Charles Nicolle, Tunis, Tunisia


American Journal of Medical Case Reports. 2015, Vol. 3 No. 10, 319-321
DOI: 10.12691/ajmcr-3-10-4
Copyright © 2015 Science and Education Publishing

Cite this paper:
Imene Boukhris, Samira Azzabi, Ines kechaou, Eya Chérif, Chékib Kooli, Nédia Znaidi, Lamia Ben Hassine, Narjess Khalfallah. Exceptional Cause of Massive Lymph Node Enlargement: Primary Localized Amyloidosis. American Journal of Medical Case Reports. 2015; 3(10):319-321. doi: 10.12691/ajmcr-3-10-4.

Correspondence to: Imene  Boukhris, Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia. Email: imen.boukhris@laposte.net

Abstract

Amyloidosis is very rarely the cause of lymph node enlargement. In the localized form of the disease, amyloidosis commonly attains the bladder, the lung and the skin. Lymph node amyloid deposition is very unusual in the localized form of the disease. In particular, cervical and mediastinal sites are uncommon. We report an exceptional case of primary localized AL amyloidosis presenting as generalized lymph node enlargement. Our patient was initially treated by colchicine but in front of disease progression, a treatment with prednisone and melphalan was necessary for stabilization. Clinician should consider primary amyloidosis in the check-list of etiologies causing lymph node enlargement.

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