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Nagasawa, A., Yoshimura, K., Suzuki, R., Mikamo, A., Yamashita, O., Ikeda, Y., Tsuchida, M., Hamano, K, “Important role of the angiotensin II in producing matrix metalloproteinase-9 in human thoracic aortic aneurysms”, J Surg Res, 183, 472-477, 2013.

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Article

Monitoring of Thoracic Aortic Aneurysm in Blood by Fluorescence Spectroscopy

1Department of Medical and Clinical Biochemistry, Pavol Jozef Šafárik University, Faculty of Medicine, Košice, Slovakia

2Department of Cardiovascular Surgery, Pavol Jozef Šafárik University, Faculty of Medicine and VUSCH, Košice, Slovakia

3Institute of Physics, Pavol Jozef Šafárik University, Faculty of Science, Košice, Slovakia


American Journal of Medical and Biological Research. 2015, Vol. 3 No. 5, 128-132
DOI: 10.12691/ajmbr-3-5-2
Copyright © 2015 Science and Education Publishing

Cite this paper:
Zuzana Guľašová, Vladimíra Tomečková, Miroslava Bilecová-Rabajdová, Beáta Veliká, Panayotis Artemiou, Vladimír Komanický, Mária Mareková. Monitoring of Thoracic Aortic Aneurysm in Blood by Fluorescence Spectroscopy. American Journal of Medical and Biological Research. 2015; 3(5):128-132. doi: 10.12691/ajmbr-3-5-2.

Correspondence to: Zuzana  Guľašová, Department of Medical and Clinical Biochemistry, Pavol Jozef Šafárik University, Faculty of Medicine, Košice, Slovakia. Email: gulasova.z@gmail.com

Abstract

Components of the blood plasma and serum represent a mixture of various endogenous substances with fluorescence properties. The aim of this work was a detection of pathological changes in blood of patients with thoracic aortic aneurysm by fluorescence spectroscopy and atomic force microscopy. The resulting autofluorescence of fluorophores in blood of patients with thoracic aortic aneurysm decreased in comparison with healthy subjects. The structure of the thoracic aorta was changed during the thoracic aortic aneurysm, what was manifested as the structural modifications in blood of patients observed by using atomic force microscopy. The fluorescence analysis and atomic force microscopy present new experimental ways in the study of the thoracic aortic aneurysm.

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