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Article

Evaluation of the Toxicity of Hemizygia bracteosa (Benth) Plant Used in Traditional Medicine for the Treatment of Diabetes Mellitus in Benin

1Laboratory of Teaching and Research in Food Microbiology, DSepartment of Food Technology Engineering, Polytechnic School of Abomey, University of Abomey, 01P.BP 2009 Cotonou, Benin

2Laboratory of Study and Research in Applied Chemistry, Polytechnic School of Abomey, University of Abomey-calavi, 01 BP 2009 Cotonou, Benin.

3Laboratory of Cytogenetic, Human Biology Unit, Faculty of Health Sciences / University of Abomey-calavi, Benin

4Association for the Promotion of Tropical Medicinal Plants (APTMP), 03 BP 246 Cotonou, Benin


American Journal of Biomedical Research. 2015, Vol. 3 No. 3, 40-44
DOI: 10.12691/ajbr-3-3-2
Copyright © 2015 Science and Education Publishing

Cite this paper:
Nicodème W CHABI, Christian T. R. KONFO, Marius ADJAGBA, Loukman MOUSSEDIKOU, Edwige AHOUSSI-DAHOUENON, Anatole LALEYE, Christophe GBAGUIDI, Mohamed Mansourou SOUMANOU. Evaluation of the Toxicity of Hemizygia bracteosa (Benth) Plant Used in Traditional Medicine for the Treatment of Diabetes Mellitus in Benin. American Journal of Biomedical Research. 2015; 3(3):40-44. doi: 10.12691/ajbr-3-3-2.

Correspondence to: Christian  T. R. KONFO, Laboratory of Study and Research in Applied Chemistry, Polytechnic School of Abomey, University of Abomey-calavi, 01 BP 2009 Cotonou, Benin.. Email: konfo01@yahoo.fr, nicodeme.chabi@gmail.com

Abstract

This study aims to assess the toxicity of Hemizygia bracteosa (Benth), a medicinal plant used for the treatment of diabetes mellitus in Benin. Wistar rats were force-feeded by using solutions obtained by dissolving the powder of this plant in distilled water. The assessment of biochemical parameters (blood glucose, triglycerides, cholesterol, HDL cholesterol, proteins) of Wistar rat serum was used to highlight the hypoglycaemic properties of this plant and its effects on cardiovascular risk factors. The results showed an increase in HDL-cholesterol levels (0.13 ± 0.004 vs 0.48 ± 0.15) and a decrease in total cholesterol levels (1.06 ± 0.40 vs 0.81 ± 0.12), triglycerides (1.2 ± 0.43 vs 1.18 ± 0.38), glucose (1.60 ± 0.25 vs 0.98 ± 0.24) and proteins (95. 33 ± 20.59 vs 58.30 ± 6.26) in rats serum after one month treatment. No significant differences were observed in control rats for all parameters. our data also shows that at concentrations from 2 g/kg this plant appears topresent significant toxicity on kidneys and liver. The use of this plant for diabetes treatment must be done with caution and doses must be controlled.

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