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Aisa, Y., “Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways,” Am J Hematol, 78(1) .7-14. Jun. 2005.

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Article

A Case of Symptomatic Inflammatory Tongue Treated with Fucoidan

1Department of Biochemistry, Nippon Dental University School of Life Dentistry at Niigata, Hamaura-cho, chuo-ku, Niigata, Japan

2Tsubura Dental Clinic, Utsunomiya, Tochigi, Japan


American Journal of Medical Case Reports. 2015, Vol. 3 No. 8, 250-254
DOI: 10.12691/ajmcr-3-8-8
Copyright © 2015 Science and Education Publishing

Cite this paper:
Shuichi Tsubura, Yoshie Waki, Tsutomu Tsubura. A Case of Symptomatic Inflammatory Tongue Treated with Fucoidan. American Journal of Medical Case Reports. 2015; 3(8):250-254. doi: 10.12691/ajmcr-3-8-8.

Correspondence to: Shuichi  Tsubura, Department of Biochemistry, Nippon Dental University School of Life Dentistry at Niigata, Hamaura-cho, chuo-ku, Niigata, Japan. Email: tshu@ucatv.ne.jp

Abstract

Abnormalities of symptomatic inflammatory tongue (SIT) present a diagnostic and therapeutic dilemma for clinicians. In particular, atrophic glossitis or fissured tongue is often linked to underlying semi-pathological conditions such as immunodeficiency, nutritional deficiency, or the effects of pharmacotherapy. The various therapies for this condition include corticosteroid ointment, anesthetic gel, anti-inflammatory drugs, and vitamin B12 supplementation to address the symptoms. However, none of these treatments has been evaluated rigorously. The case of an adult patient in which persistent, painful SIT was successfully treated using a 32% fucose chewable tablet is presented. In this case, PC-320TM achieved marked improvements in SIT. Clinical trials are needed to confirm the efficacy and safety of topical PC-320 in treating SIT.

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