Mande Qiu^{1, 2,}, Aimei Dai¹, Pan Yang¹, Miao Niu¹, Yidan Wang¹, Guoyi Bai¹

The physical and chemical properties of the materials are generally determined by their microstructure and main components. In this paper, the Hap/Cs-Cmc composite materials with different mass ratios were prepared for the first time through liquid co-precipitation method. The microstructure, phase and performance of the composite materials were investigated by FT-IR, XRD, TG-DTA, SEM, and EDS respectively. The purpose of this work is to establish the relationship between material microstructures and properties. The results showed that the composite materials exhibited excellent mechanical performance and thermal stability. The nano-Hap with relatively good crystallinity were dispersed uniformly in the organic phase Cs and Cmc-combined with relatively closely between Hap particles and Cs-Cmc. The particle size of the material is about 50 nm with spherical shape. The mass ratio of Hap and Cs-Cmc directly influenced the crystallization, particle size, and dispersion of Hap. When mass ratio is 50/50, the uniformity, compactness, and thermal stability were the best and the compressive strength is up to 30.5 MPa. EDS analysis showed that the composite material merely contained trace amount of sodium and the ratio of calcium and phosphorus is around 1.85, belonging to the rich calcium type of Hap, and the physical and chemical performance totally met the requirements of bone tissue engineering materials.

nano-hydroxyapatite, chitosan, carboxymethyl cellulose, composite materials, microanalysis