Article citationsMore >>

Paget, G. E. and Barnes, J. M., Toxicity tests in evaluation of drug activities pharmacometries (Laurence, D. R. and Bacharach, A. L. eds) Academic Press, London and New York, 1964.

has been cited by the following article:

Article

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

1Zoology Department, Faculty of Science, Menoufia University, Egypt

2Zoology Department, Faculty of Science, Benha University, Egypt


American Journal of Biomedical Research. 2013, Vol. 1 No. 1, 1-6
DOI: 10.12691/ajbr-1-1-1
Copyright © 2013 Science and Education Publishing

Cite this paper:
Saber A. Sakr, Mohammed E. Zoail, Samraa S. El-Shafey. Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice. American Journal of Biomedical Research. 2013; 1(1):1-6. doi: 10.12691/ajbr-1-1-1.

Correspondence to: Saber A. Sakr, Zoology Department, Faculty of Science, Menoufia University, Egypt. Email: sabsak@yahoo.com

Abstract

The present work studied the cytogenetic and testicular damage induced by the antiarrhythmic drug rytmonorm (RT) and the protective role of grapefruit juice in albino rats. Treating rats with RT (13.5mg/Kg bodyweight) for five weeks caused a significant increase in the percentage of chromosomal aberrations either structural or numerical and decrease the mitotic index. Using comet assays, RT caused DNA fragmentation in the lymphocytes. Testis of RT treated rats showed many histopathological and morphometric alterations. In addition, the number of sperm head abnormalities was increased. Treating animals with RT and grapefruit juice (27ml/Kg bodyweight) led to an improvement in chromosomal aberrations, mitotic index, DNA damage, and testicular alterations caused by RT. In conclusion, the results of this study indicated that grapefruit juice showed a protective effect on cytotoxicty and testicular alterations induced by RT in albino rats and this is may be due to its potent antioxidant effects.

Keywords