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Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. 2002. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138: 1462-1470.

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Article

Effect of Adipose-derived Mesenchymal Stem Cells in Photoaging Balb/C Mouse Model

1Department of Dermatology, PelitaHarapan University, Tanggerang, Indonesia

2Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin UniversitySouth of Sulawesi, Makasar, Indonesia

3Primate Center, Bogor Agricultural Institute, Bogor, Indonesia

4Department of Physiology, Faculty of Medicine, Hasanuddin UniversitySouth of Sulawesi, Makasar, Indonesia


American Journal of Medical and Biological Research. 2015, Vol. 3 No. 1, 48-52
DOI: 10.12691/ajmbr-3-1-4
Copyright © 2015 Science and Education Publishing

Cite this paper:
Muljani Enggalhardjo, Syarifuddin Wahid, Dondin Sajuthi, Irawan Yusuf. Effect of Adipose-derived Mesenchymal Stem Cells in Photoaging Balb/C Mouse Model. American Journal of Medical and Biological Research. 2015; 3(1):48-52. doi: 10.12691/ajmbr-3-1-4.

Correspondence to: Muljani  Enggalhardjo, Department of Dermatology, PelitaHarapan University, Tanggerang, Indonesia. Email: mulyanienggalhardjo@yahoo.com

Abstract

Cell therapy using stem cells restores organs or tissue damaged by trauma, include of photoaging. Adiposed-derived stem cell (ADSC) have relative advantages in accessibility (less invasif), abundance stem cell compared to other kinds of stem cell and easier to get adipose in large quantities than bone marrow. In this Study, we investigated whether subcutaneous injection of ADSC significantly increase collagen synthesis, epidermis and dermis thickness, colagen density, and microvascular density in Photoaging Balb/C mice. We use 27 mice, divided by 3 group. The first group (A) were given UVB light irradiation and stem cell. The B group were given UVB light irradiation and placebo (NaCl 0.9%). The C group as the control group was untreated (no UVB light irradiation and no stem cells).The results showed that 1x104 ADSC subcutaneuous injection significantly increase collagen synthesis in Balb/C mice and collagen density in photoaging. In conclusions revealed that Adiposed-derived Mesenchymal stem cells stimulate colagen density, and improved photoaging.

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