In recent years, stem cell research has grown exponentially due to the recognition that stem cell-based therapies have the potential to improve the life of patients with wide range of conditions, they provides promising methods in vitro as well as in vivo in animal models which make speculation about a future application in human dentistry reasonable. Based on their ability to repair and/or rescue injured tissue and restore organ function even partially, multiple types of stem/progenitor cells have been speculated. Some dental tissues are rich source of mesenchymal stem cells which are suitable for tissue engineering applications. Because they have the potential to differentiate into several cell types, including odontoblasts, neural progenitors, osteoblasts, chondrocytes, and adipocytes. Based on that, an innovativation for generation of clinical material and/or tissue regeneration carried out. Mesenchymal stem cells were founded in dental tissues, including dental pulp, dental papilla, and dental follicle, exfoliated deciduous teeth and periodontal ligament. They can be isolated and grown under defined tissue culture conditions, and used in tissue engineering, including, dental tissue, nerves and bone regeneration.

regeneration, stem cells, periodontal tissues, cloning, mesenchymal cells