eng Science and Education Publishing World Journal of Organic Chemistry 2372-2169 2017-04-19 5 1 1 5 10.12691/wjoc-5-1-1 WJOC2017511 article Synthesis and Chemical Reactivity of some new Fluorine Substituted Pyrazolopyrimidine Derivatives and Their Effect on Cellobiase Activity Produced by Fungi Reda Abdul-Rahman 1 Dina Abed Bakhotmah, Montaha Fakhorji mfahkurji@stu.kau.edu.sa 1 Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Various fluorine substituted fused heteropolycyclic nitrogen systems containing a pyrazolopyrimidine moieties have been synthesized from the interaction between 6-mercaptopyrazolo[3,4-d]pyrimidines with bifunctional nitrogen and halogen compounds. The effect of these fluorinated systems on the activity of the cellobiase produced by Aspergillus Nidulans was evaluated. The outcome of the study discloses that, some of the compounds have shown promising activity in low concentration. http://pubs.sciepub.com/wjoc/5/1/1/wjoc-5-1-1.pdf fused heteropolycyclic Aspergillus Nidulans pyrazolopyrimidine cellobiase fungi 6-mercaptopyrazolo fluoro heteropolycyclic