Science and Education Publishing World Journal of Organic Chemistry 2372-2169 4 1 2016 8 19 Constituents of the Jamaican Sponge Iotrochota birotulata 13 16 EN Monique N. Thompson Winklet A. Gallimore Department of Chemistry, University of the West Indies, Mona Campus, Kingston, Jamaica WJOC2016413 10.12691/wjoc-4-1-3 2016 2 24 2016 6 19 2016 8 17 Iotrochota birotulata, an abundantly occurring sponge collected off the coast of Port Royal, Jamaica was investigated to identify its main constituents and evaluate the bioactivity associated with its crude extracts. The compounds renierapurpurin and the tyrosine derivative 1,3-dibromo-5-{2-[(p-hydroxyphenyl)-acetamido]ethyl}-2-[3-(-methyl-2-butenamido)-propoxy] benzene were isolated from the crude extract along with the common steroid β-sitosterol. The carotenoid derivative renierapurpurin was identified in this species for the first time. The structures of these compounds were elucidated using spectral analysis. When the crude extracts of the sponge were tested against the sweet potato weevil Cylas formicarius elegantulus, 100% mortality was observed at a concentration of 2 µg/mL after 72 hours.