@article{wjoc2014212,
author={Halawa, Ahmed Hamdy},
title={Synthesis, Reactions and Biological Evaluation of Some Novel 5-Bromobenzofuran-Based Heterocycles},
journal={World Journal of Organic Chemistry},
volume={2},
number={1},
pages={9--17},
year={2014},
url={http://pubs.sciepub.com/wjoc/2/1/2},
abstract={Condensation of 2-acetyl-5-bromobenzofuran with hydrazine derivatives <b>2a,b</b> afforded hydrazone derivatives <b>3a,b</b>, which reacted with alkyl halides<b>4a,b</b> to yield ethylidene derivatives <b>5a,b</b>. Also, <b>3a</b> reacted with hydrazonyl halides<b>6a,b</b> to give 1,3,4-thiadiazole derivatives <b>9a,b</b>. Thiosemicarbazone<b>3b</b> was reacted with acetic anhydride and halogenated compounds to afford the corresponding heterocyclic derivatives <b>10, 11a,b, 12-17</b> and <b>18a,b</b>.Moreover, interaction of <b>16</b> with tetracyanoethylene and salicyldehyde derivatives furnished <b>24</b> and <b>26a,b</b>, respectively. Finally, reaction of <b>16</b> with DMF-DMA afforded enaminone<b>29</b>, which on treatment with different heterocyclic amines yielded <b>31</b> and <b>33</b> respectively. Some of the newly synthesized compounds showed promising antimicrobial activity.},
doi={10.12691/wjoc-2-1-2}
publisher={Science and Education Publishing}
}