Copper-Catalyzed Hydroamination of Terminal Alkynes by Combining N-fluorobenzenesulfonimide and H2O: Synthesis of β-amino Substituted Styrenes

eng Science and Education Publishing World Journal of Organic Chemistry 2372-2169 2023-11-27 10 1 4 19 10.12691/wjoc-10-1-2 WJOC20231012 article Copper-Catalyzed Hydroamination of Terminal Alkynes by Combining N-fluorobenzenesulfonimide and H2O: Synthesis of β-amino Substituted Styrenes Tony Wheellyam Pouambeka tonywheellyam@yahoo.fr 1 2 Hubert Makomo 2 Ghislain Kende 2 Timoléon Andzi Barhé 3 Equipe de Chimie Organique et Analytique des Substances Bioactives, Faculté des Sciences et Techniques, Université Marien Ngouabi, Brazzaville, République du Congo BP 69 Laboratoire de Recherche en Chimie Appliquée, Ecole Normale Superieure, Université Marien Ngouabi, Brazzaville, République du Congo BP 69 By using the combining of N-fluorobenzenesulfonimide and H2O, we have realized the first example of high efficient and easy hydroamination of terminal alkynes. The reaction was catalyzed by copper and the corresponding β-amino substituted styrenes have been afforded in good to excellent yields. The transformation under simple mild conditions feature a broad substrate scope, atom economy, good functional group tolerance and the simple mechanism was proposed. The different products obtained were characterized using 1HNMR, 13CNMR and HRMS. http://pubs.sciepub.com/wjoc/10/1/2/wjoc-10-1-2.pdf hydroamination β-amino substituted styrenes N-fluorobenzenesulfonimide (NFSI) Copper-Catalyzed