Science and Education Publishing World Journal of Organic Chemistry 1 1 2013 09 25 Short Review on Synthesis of Thiazolidinone and β-Lactam 24 51 EN N. A. A. Elkanzi Chemistry Department, Aswan-Faculty of Science, Aswan University, Aswan, Egypt WJOC2013124 10.12691/wjoc-1-2-4 2013 04 26 2013 08 20 2013 09 25 The review summarizes literature dealing with the synthesis of thiazolidinoneand ¦-lactamVarious methods for synthesis of thiazolidinone and ¦-lactamare discussed. Like boiling benzene thioglycolic acid was added to (1)a-d using a water separator to give thiazolidinone derivatives (2)a-d. Also Reaction of the Schiff bases of 3 and /or5 with one mole of thioglycolic acid was proceeded smoothly to afford the corresponding thiazolidinone derivatives 6,7 respectively. The synthesis of a new type of compound, 2-hydrazolyl-5,5-diphenyl-4-thiazolidinone (24), obtained by treatment of thiosemicarbazone with benzyl in basic media. ¦-lactams were prepared by N-Tosyl-3-halo-3-butenylamines underwent efficient Ullmann-type coupling to afford 2-alkylideneazetidines, which could be readily converted to the corresponding ¦-lactams by oxidation with O₃ to give ¦-lactams 119. A chiral N-heterocyclic carbene catalyzed the Staudinger reaction of arylalkylketenes with a variety of N-tert-butoxycarbonylarylimines to give the corresponding cis-¦-lactams 124.