eng Science and Education Publishing World Journal of Chemical Education 2375-1657 2021-05-15 9 2 50 56 10.12691/wjce-9-2-3 WJCE2021923 article Jitendra M. Pawara jmpawara@gmail.com 1 Sunil S. Patil 1 Department of Chemistry, Changu Kana Thakur Arts Commerce and Science College (Autonomous), New Panvel, Maharashtra, India In the present work, a series of new mixed ligand Ni(II) complexes of the type [Ni(P)(L).2H2O] have been synthesized by using 2-amino-6-methyl pyrimidine-4-ol (HP), a primary ligand and N- and O- donor amino acids (HL) secondary ligands. Synthesis of Ni(II) complexes has been carried out by thermal and microwave methods. Results show that complexes synthesized by the microwave method were more efficient than the thermal method. Preparation time in the microwave method was short (4-7 min.) as compared to the thermal method (45 min.). Additionally, the microwave technique gave a very high yield (90%) of the complexes. The prepared complexes were characterized by Gouy experiment, FTIR, elemental analysis, TGA, and DTA at room temperature. The complexes have shown considerable antimicrobial activities such as antifungal and antibacterial activity. http://pubs.sciepub.com/wjce/9/2/3/wjce-9-2-3.pdf Ni(II) complexes 2-amino-6-methyl pyridine-4-ol amino acids microwave antimicrobial activity