eng Science and Education Publishing World Journal of Chemical Education 2375-1657 2019-09-29 7 4 242 247 10.12691/wjce-7-4-2 WJCE2019742 article Mohammed A. Meetani mmeetani@uaeu.ac.ae 1 Ahmad Alhalabi 2 Mohammed K. Al-tabaji 2 Noor I Albadawi 2 Nada Elmari 2 Soleiman Hisaindee 2 Abdullah Al-Hemyari 2 Munjed Maraqa 2 Chemistry Department, College of Science, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE Civil and Environmental Engineering Department, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase. http://pubs.sciepub.com/wjce/7/4/2/wjce-7-4-2.pdf dapsone β-cyclodextrin fluorescence guest-host interaction wastewater