Greener Synthesis of an Amide by Direct Reaction of an Acid and Amine under Catalytic Conditions

eng Science and Education Publishing World Journal of Chemical Education 2375-1657 2015-03-10 3 1 27 29 10.12691/wjce-3-1-4 WJCE2015314 article Greener Synthesis of an Amide by Direct Reaction of an Acid and Amine under Catalytic Conditions Gabriel Arce 1 Gonzalo Carrau 1 Ana Bellomo 1 David Gonzalez davidg@fq.edu.uy 1 Depto. de Química Orgánica, Facultad de Química, Universidad de la República (UdelaR), Montevideo, Uruguay A simple and high-yielding laboratory experiment that involves the boric acid catalyzed amidation of benzoic acid is described. The experiment makes use of recent chemistry, it is appropriate for advanced undergraduate chemistry students, and demonstrates several important concepts including homogeneous catalysis and green chemistry. http://pubs.sciepub.com/wjce/3/1/4/wjce-3-1-4.pdf Upper-Division Undergraduate organic chemistry green chemistry catalysis amides