eng Science and Education Publishing World Journal of Chemical Education 2375-1657 2023-09-06 11 3 97 103 10.12691/wjce-11-3-13 WJCE202311313 article Antonia Fruntke 1 Nicolai ter Horst 1 Christoph Bley 1 Benedikt Bl¨¹mbott 1 Mira Behnke 2 3 Leanne M. Stafast 3 3 Antje Vollrath 3 3 Ulrich S. Schubert 3 3 Timm Wilke timm.wilke@uni-jena.de 3 3 Institute for Inorganic and Analytical Chemistry, Chemistry Education, Friedrich Schiller University Jena, August-Bebel-Stra?e 2, 07743 Jena, Germany This publication introduces a digital learning module on the topic of nanomedicine for chemistry education in high schools and for student laboratories. Nanoparticles provide a modern approach for treating diseases. By encapsulating active ingredients in nanoparticles the ingredients are not distributed in the entire body, but can be specifically transported and released to the target organs and tissues. The advantage of this approach is that a higher dose can reach the designated target while minimizing the overall dosage and resulting side effects. This research topic offers excellent links to classical school chemistry contents such as polymer chemistry, polymerization, ester formation and cleavage, polarity, and solubility. The digital learning module is based on a differentiation grid that offers students with varying learning backgrounds an individual way to access and engage with the module. http://pubs.sciepub.com/wjce/11/3/13/wjce-11-3-13.pdf drug delivery nanomedicine digitalization polyesters nanoparticle esterification hydrolysis high school / introductory chemistry first-year undergraduate / general laboratory differentiation grid