@article{jmpc20221021,
author={{ASSOMA, Amon Benjamine and COULIBALI, Siomenan and CAMARA, Tchambaga Etienne and ACHI, Patrick-Armand and ADJOU, Ane},
title={QSAR Study of 2-benzylthiopyrimidine Derivatives with Antibacterial Activity on Staphylococcus Aureus},
journal={Journal of Materials Physics and Chemistry},
volume={10},
number={2},
pages={36--42},
year={2022},
url={http://pubs.sciepub.com/jmpc/10/2/1},
issn={2333-4444},
abstract={This work presents a Quantitative Structure-Activity Relationship (QSAR) study of twenty new 2-benzylthioprymidine derivatives that possess antibacterial activity. The antibacterial activity of these compounds was evaluated on a multi-resistant <i>Staphylococcus aureus</i> (<i>S. aureus</i>) strain. The concentrations that inhibit 50% of <i>S. aureus</i> (IC<SUB>50</SUB>) were determined as antibacterial parameters by the microdilution method. The results revealed that all the synthesized compounds showed significant antibacterial activity against the tested germ. A mathematical relationship was established by Non-Linear Multiple Regression (NLMR) between the potential inhibitory concentration (PIC<SUB>50</SUB>) of the twenty compounds and physicochemical parameters such as the Partition coefficient (LogP), the Molar Volume (MV), the Ionisation Potential (IP), the Electronic Affinity (EA) and the Carbon-Sulfur bond length [l(C-S)]. This mathematical relationship will be used to predict the antibacterial activity of other 2-benzylthioprymidine derivatives.},
doi={10.12691/jmpc-10-2-1}
publisher={Science and Education Publishing}
}