eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2021-06-28 9 6 292 296 10.12691/jfnr-9-6-4 JFNR2021964 article Yung-Kai Lin 1 2 3 Yu-Yu Kao 4 Cheng Liu 5 Chia-Hua Liang 6 Yung-Hsiang Lin 7 Wei-Chun Hu 7 Chi-Fu Chiang Jimmy.Chiang@tci-bio.com 7 Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan Shanghai Daerwei Biotechnology R&D Co., Ltd., Shanghai, China Department of Health and Beauty, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan Research & Design Center, TCI CO., Ltd., Taipei, Taiwan Vegetables and fruits had antioxidant capacity. Fermented grapes had a higher content of anthocyanins and flavonoids, and reduced skin wrinkles. There were not more clinical studies on whether fermented grapes with fruit and vegetable extracts had anti-aging and anti-inflammatory activities. The current study used fermented grapes beverages made from fermented grapes combined with fruit and vegetable extracts to explore anti-aging and anti-inflammatory. 60 subjects were recruited and divided into a placebo and another fermented grape drinks group. The subjects drank 50 ml , 1 bottle a day for 8 week. After drinking for 8 weeks, a skin test and blood inflammatory factor analysis were performed. Compared to the placebo group, skin brightness, moisture, elasticity was significantly increased by 3.6%, 4.9%, 5.4%, respectively. Fermented grape drinks decreased skin spots, and wrinkles by 7.0%, and 19.0%, respectively. TNF-¦Á (Tumor Necrosis Factor) and IL-6 (Interleukin-6) expression were decreased, also, as a function of fermented grape drinks intakes. This study indicated that fermented grapes combined with fruit and vegetable extracts can significantly improve the brightness, moisture, elasticity, wrinkles, pores, and decrease TNF-¦Á and IL-6 expression. http://pubs.sciepub.com/jfnr/9/6/4/jfnr-9-6-4.pdf fruit vegetable grapes inflammation skin aging