@article{jfnr2021926,
author={{Kasai, Hiroshi and Kawasaki, Yuya and Kawai, Kazuaki},
title={1,4-Dihydroxy-2-naphthoic Acid Sulfate: A Promising Constipation Preventive Agent},
journal={Journal of Food and Nutrition Research},
volume={9},
number={2},
pages={96--101},
year={2021},
url={http://pubs.sciepub.com/jfnr/9/2/6},
issn={2333-1240},
abstract={1,4-Dihydroxy-2-naphthoic acid (DHNA) is a metabolic by-product of fermentation by <i>Propionibacterium</i> and is thought to have a beneficial effect as a prebiotic. As it is unstable in air, we have developed a new stable DHNA derivative, DHNA-4-sulfate (DHNAS), which should be converted to DHNA <i>in vivo</i>. After DHNAS was administered to mice, fecal size enlargement and softening were observed. As a metabolite, DHNA-4-&#946;-glucuronide (DHNAG) was detected in the urine, which suggested the sequential conversion, DHNAS<font face='wingdings'>&#224;</font>DHNA<font face='wingdings'>&#224;</font>DHNAG, <i>in vivo</i>. These 4-OH-blocked DHNA derivatives, DHNAS and DHNAG, were stable at pH 3 and pH 7.4, and in water, while DHNA decomposed rapidly within 20 hrs. DHNAS may be a useful food additive to improve human intestinal health, and a promising constipation preventive agent.},
doi={10.12691/jfnr-9-2-6}
publisher={Science and Education Publishing}
}