eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2021-12-01 9 12 614 625 10.12691/jfnr-9-12-1 JFNR20219121 article Jihee Lee 1 Inae Jeong 1 Gwang-Woo Kim 1 Taesang Son 1 Yujeong Kim 1 Woojin Jun 1 2 Jeongjin Park 2 2 Ok-Kyung Kim 20woskxm@jnu.ac.kr 2 2 Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea We investigated whether standardized ethanolic extracts of Boswellia (FJH-BS) could alleviate the symptoms of osteoarthritis, including pain, inflammation, and degradation of articular cartilage. Sprague-Dawley rats with monosodium iodoacetate (MIA)-induced osteoarthritis received supplementation of FJH-BS at 80 and 125 mg/kg body weight. We found that FJH-BS supplementation reduced histological and architectural changes and pain levels in rats with MIA-induced osteoarthritis. In addition, FJH-BS supplementation suppressed mRNA expression of matrix metalloproteinases (MMPs) and pro-inflammatory mediators, including cyclooxygenase-2, prostaglandin E2, and pro-inflammatory cytokines. Furthermore, FJH-BS treatment directly suppressed cell death, inflammation, and expression of MMPs in H2O2- or LPS-treated primary chondrocytes. Our results suggest that supplementation with standardized FJH-BS may prevent osteoarthritis progression by directly influencing chondrocytes. http://pubs.sciepub.com/jfnr/9/12/1/jfnr-9-12-1.pdf Boswellia osteoarthritis chondrocytes