@article{jfnr20219121,
author={{Lee, Jihee and Jeong, Inae and Kim, Gwang-Woo and Son, Taesang and Kim, Yujeong and Jun, Woojin and Park, Jeongjin and Kim, Ok-Kyung},
title={Standardized Ethanolic Extracts of <i>Boswellia serrata </i>Ameliorate Symptoms of Osteoarthritis by Direct Effects on Chondrocytes},
journal={Journal of Food and Nutrition Research},
volume={9},
number={12},
pages={614--625},
year={2021},
url={http://pubs.sciepub.com/jfnr/9/12/1},
issn={2333-1240},
abstract={We investigated whether standardized ethanolic extracts of Boswellia (FJH-BS) could alleviate the symptoms of osteoarthritis, including pain, inflammation, and degradation of articular cartilage. Sprague-Dawley rats with monosodium iodoacetate (MIA)-induced osteoarthritis received supplementation of FJH-BS at 80 and 125 mg/kg body weight. We found that FJH-BS supplementation reduced histological and architectural changes and pain levels in rats with MIA-induced osteoarthritis. In addition, FJH-BS supplementation suppressed mRNA expression of matrix metalloproteinases (MMPs) and pro-inflammatory mediators, including cyclooxygenase-2, prostaglandin E<SUB>2</SUB>, and pro-inflammatory cytokines. Furthermore, FJH-BS treatment directly suppressed cell death, inflammation, and expression of MMPs in H<SUB>2</SUB>O<SUB>2</SUB>- or LPS-treated primary chondrocytes. Our results suggest that supplementation with standardized FJH-BS may prevent osteoarthritis progression by directly influencing chondrocytes.},
doi={10.12691/jfnr-9-12-1}
publisher={Science and Education Publishing}
}