eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2020-08-13 8 8 399 409 10.12691/jfnr-8-8-3 JFNR2020883 article Catalina Mar¨ªn-Echeverri 1 Manuela Piedrahita-Bland¨®n 1 Yeisson Galvis-P¨¦rez 1 Vitelbina Nu?ez-Rangel 1 Christopher N. Blesso 2 Mar¨ªa-Luz Fern¨¢ndez 2 Jacqueline Barona-Acevedo maria.barona@udea.edu.co 2 Research Group of Toxinology, Therapeutic and Food Alternatives; School of Microbiology; Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medell¨ªn, Colombia Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA Obesity implies higher cardiovascular risk (CVR) than overweight. Polyphenol-rich fruits have shown to ameliorate CVR factors (CVRF). It is not clear whether differential effects could be observed between obese and overweight people consuming these fruits. Objective: To evaluate the effects of agraz on CVRF in overweight and obese women with metabolic syndrome (MetS). Methods: Overweight (n=22) and obese (n=18) women (25-60 years) with MetS, were included in this crossover, double-blind and placebo-controlled study. They consumed agraz or placebo over 4-weeks separated by a 4-wk washout period. At the end of each period, the following parameters were measured: anthropometrics, blood pressure, serum lipid profile, glucose, insulin, adipokines, apolipoprotein (apo)-A1, high sensitivity C-reactive protein (hs-CRP), serum total antioxidant capacity (TAC), endogenous antioxidant enzymes and oxidative stress (OxS) markers. Results: Compared to placebo, agraz consumption significantly (p<0.05) reduced hs-CRP and urinary 8-hydroxy 2 deoxyguanosine (8-OHdG) levels in overweight and obese women, respectively. In both groups, changes in antioxidant markers were significant (p<0.05) and negatively correlated with changes in CVR factors and OxS markers, respectively. Positive correlations were observed with cardioprotective markers. Conclusions: Agraz consumption had differential effects in overweight and obese women, with better effects on inflammation and OxS markers, respectively. Further studies should consider these differential responses when analyzing the results of an intervention, and eventually adjust to get better outcomes. http://pubs.sciepub.com/jfnr/8/8/3/jfnr-8-8-3.pdf Andean berry obesity oxidative stress total antioxidant capacity antioxidant enzymes inflammation cardiovascular risk factors