@article{jfnr2020872,
author={{Liu, Ching-Chih and Chen, Jen-Yin and Chu, Chin-Chen and Chen, Shih-Ying and Chu, Heuy-Ling and Duh, Pin-Der},
title={Chlorogenic Acid Decreases Lipid Accumulation in 3T3-L1 Adipocytes by Modulating the Transcription Factors},
journal={Journal of Food and Nutrition Research},
volume={8},
number={7},
pages={313--319},
year={2020},
url={http://pubs.sciepub.com/jfnr/8/7/2},
issn={2333-1240},
abstract={The aim of this study is to investigate the effect of chlorogenic acid (CA) on 3T3-L1 adipocytes and its mechanism action. CA at 1-25 ¦ÌM showed no cytotoxicity to 3T3-L1 pre-adipocytes and 3T3-L1 adipocytes. CA significantly inhibited oil red O-stained material (OROSM) and intracellular triglyceride levels in 3T3-L1 adipocytes in a concentration-dependent manner. In addition, CA down-regulated the glycerol-3¨Cphosphate dehydrogenase (GPDH) and peroxisome proliferator¨Cactivated receptor ¦Ã (PPAR¦Ã) activity. A real-time polymerase chain reaction revealed that CA inhibited the PPAR¦Ã, CCAAT/enhancer-binding protein alpha (C/EBP¦Á), sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) gene expression, which may in part account for anti-adipogenesis of CA. Thus, CA could act as a potential lipid lowering functional resource.},
doi={10.12691/jfnr-8-7-2}
publisher={Science and Education Publishing}
}