@article{jfnr2020865,
author={{Derosa, Giuseppe and Gaudio, Giovanni and DĄŻAngelo, Angela and Maffioli, Pamela},
title={Evaluation in Patients with High NORMAL Blood Pressure of a Supplement Containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzime Q10 and Vitamin B1: A PILOT Study},
journal={Journal of Food and Nutrition Research},
volume={8},
number={6},
pages={273--278},
year={2020},
url={http://pubs.sciepub.com/jfnr/8/6/5},
issn={2333-1240},
abstract={<b>Aim: </b>to evaluate the effects of a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 in patients with high normal blood pressure on the levels of systolic (SBP) and diastolic blood pressure (DBP). <b>Methods:</b> we enrolled 40 patients of both sexes, with high normal pressure (SBP values between 130-139 mmHg and/or DBP between 85-89 mmHg) according to the 2018 ESC/ESH Guidelines for the management of arterial hypertension. Patients were consecutively enrolled to take nutraceutical for 3 months and it is self-administered once a day during the breakfast. <b>Results:</b> no significant variations of BMI or circumferences were recorded with nutraceutical from baseline. A slight reduction of FPG was recorded, although this variation was not significant. Significant reductions were obtained in SBP (p&lt; 0.05) and DBP (p&lt; 0.05). No significant HR variation was observed from baseline. A significant TC and LDL-C decrease were observed after 3 months (p&lt; 0.05, respectively). No significant HDL-C, and Tg variations were obtained after 3 months. No significant reduction of Hs-CRP was recorded compared to baseline. No significant variations of transaminases were recorded during the study, and creatinine value was not significantly modified compared to baseline. <b>Conclusions: </b>a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 could be helpful in improving high normal blood pressure, and hypercholesterolemia, two of the major risk factors for vascular events.},
doi={10.12691/jfnr-8-6-5}
publisher={Science and Education Publishing}
}