eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2020-03-28 8 3 155 159 10.12691/jfnr-8-3-6 JFNR2020836 article Ping Lin 1 Kai-Wen Kan 2 Jia-Haur Chen 2 Yung-Kai Lin 3 Yung-Hao Lin 4 Yung-Hsiang Lin 4 Chen-Meng Kuan Chenmeng.Kuan@tci-bio.com 4 Research & Design Center, TCI CO., Ltd., Taipei, Taiwan Research & Design Center, TCI Gene Inc., Taipei, Taiwan Department of Animal Science, Chinese Culture University, Taipei, Taiwan Global Business Center, TCI CO., Ltd., Taipei, Taiwan This study unveils the possibility of a pear-based formula for reparatory care. Pears contain abundant polyphenols and triterpenoids in their fruit and skin, which confer antoxidative and anti-inflammatory effects on the prevention of chronic diseases. Pears have been used in several traditional remedies for reliving respiratory syndromes and constipation for over 2000 years in China. However, the use of pears for daily care is not easily accessible for most people. A pear-based sachet is a convenient approach to the beneficial ingredients of pears. The pear-based formula here enhanced wound healing rate by 27% and significantly improved the expression of allergy-, lung disease-, and DNA repair-related genes in lung cells. Moreover, the formula could increase the phagocytic activity of macrophages by 43%. In short, pear-based formula might provide the comprehensive respiratory care as evidenced by improvement in the wound healing efficiency of lung cells, the phagocytic activity of macrophages, down-regulation of the expression of respiratory disease-associated genes, and up-regulation the expression of DNA mismatch repair genes in cellular models. http://pubs.sciepub.com/jfnr/8/3/6/jfnr-8-3-6.pdf pear antioxidation phagocytosis mismatch DNA repair wound healing