eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2020-10-20 8 10 556 560 10.12691/jfnr-8-10-3 JFNR20208103 article Iker Jauregibeitia 1 Kevin Portune 1 Javier Amezaga 1 Itziar Tueros 1 Sara Arranz sarranz@azti.es 1 Basque Research and Technology Alliance (BRTA), Parque Tecnol¨®gico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio (Bizkaia), Spain Increasing evidence has shown that fatty acids play a key factor in nutrition and health. Despite the well described health benefits associated to the omega-3 fatty acids (¦Ø-3 FA) intake from epidemiological and clinical trials, controversial results are found from some clinical trials regarding the effect of ¦Ø-3 FA supplementation to handle certain diseases. In this review, we provide orientation for the reader to understand the importance of a personalized recommendation of the ¦Ø-3 polyunsaturated fatty acid supplementation based on a precision nutrition approach. We begin by reviewing the metabolic relevance of ¦Ø-3 fatty acids and then discuss the current state of ¦Ø-3 fatty acid supplements regarding their indications, regulation, variety from brand to brand, adverse effects and the need to implement a personalized supplementation. We conclude with future perspectives for practitioners and general guidance on precision nutrition. http://pubs.sciepub.com/jfnr/8/10/3/jfnr-8-10-3.pdf lipidomics omega 3 fatty acids precision nutrition health