eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2019-08-09 7 8 554 559 10.12691/jfnr-7-8-1 JFNR2019781 article Giuseppe Derosa giuseppe.derosa@unipv.it 1 2 3 Davide Romano 3 Angela D’Angelo 3 3 Pamela Maffioli 3 Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, PAVIA, Italy Aim: to evaluate the effects of a non dairy cheese cream containing fermented soybean extract compared to a dairy cheese cream on lipid profile and lipoproteins in dyslipidemic patients. Methods: patients were randomized to take, twice a day on a slice of bread, a non dairy cheese cream, containing fermented soybean extract 75% (Valsoia Lo spalmabile®), or a placebo dairy cheese cream for 3 months, in a double-blind, placebo-controlled study design. We evaluated, at baseline and after 3 months: anthropometric parameters, fasting plasma glucose (FPG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tg), lipoprotein (a) [Lp(a)], apolipoprotein A-I (Apo A-I), apolipoprotein B (Apo B), high-sensitivity C-reactive protein (Hs-CRP). Results: we did not record any variation of FPG. Total cholesterol, LDL-C and Tg decreased after 3 months with the active treatment, both compared to baseline and placebo (p < 0.05 for both). No variations were recorded with placebo. High density cholesterol did not change in neither group. We recorded a decrease of Apo-B and Hs-CRP with the active treatment, but not with placebo, compared to baseline (p < 0.05 for both), even if, in group to group comparison, only Apo-B resulted lower compared to placebo (p < 0.05). Lp(a) and Apo-A1 did not differ between treatments or compared to baseline. Conclusions: a non dairy cheese cream, containing fermented soybean extract 75%, better improved lipid profile compared to placebo dairy cheese cream in dyslipidemic patients. http://pubs.sciepub.com/jfnr/7/8/1/jfnr-7-8-1.pdf cheese cream lipid profile non dairy cheese cream soybean extract