eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2019-06-12 7 6 452 457 10.12691/jfnr-7-6-7 JFNR2019767 article Shih-Ying CHEN 1 Chin-Chen CHU 2 Yi-Chiang LIN 2 Pin-Der DUH ipdduh@mail.cnu.edu.tw 3 Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan, ROC Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ROC The aim of this study was to investigate the effect of Djulis (Chenopodium formosaneum) and its bioactive compounds on hyperlipidemia and hyperglycemia in high-fat diet (HFD)-fed mice. The study indicated that, total cholesterol (TC), and triglyceride (TG) levels were significantly higher in HFD-fed mice than in those fed with ethanolic extract of Djulis (EECF) at different doses (10, 25, 50 mg/kg bw), rutin (5 mg/kg bw), betanin (5 mg/kg bw) and quercetin (5 mg/kg bw) throughout the 12-week period, indicating alleviation of hyperlipidemia by EECF and bioactive compounds groups. Moreover, plasma insulin was significantly higher in HFD-fed mice than those fed with EECF at different doses, rutin, betanin and quercetin. In addition, results of oral glucose tolerance test (OGTT) revealed improved glucose tolerance and ameliorated insulin response at 60 and 90 min in mice fed with EECF, rutin, betanin and quercetin. The findings of this study suggest EECF has beneficial effects on hyperlipidemia and hyperglycemia of obese mice induced with HFD, which can be partly attributed to the bioactive compounds present in Djulis. http://pubs.sciepub.com/jfnr/7/6/7/jfnr-7-6-7.pdf betanin Djulis (Chenopodium formosaneum) hyperlipidemia hyperglycemia quercetin rutin