@article{jfnr2019725,
author={{PAULINO, Alice Helena S. and VIANA, Ana Maria F. and BONOMO, Larissa F. and GUERRA, Joyce Ferreira C. and LOPES, Juliana M¨˘rcia M. and RABELO, Ana Carolina S. and FAGUNDES, Miliane Martins A. and R¨¦GIS, Ana L¨˛cia Rissoni S. and LIMA, Wanderson G. and PEDROSA, Maria L¨˛cia and SILVA, Marcelo Eust¨˘quio},
title={Ara?¨˘ (<i>Psidium cattleianum</i> Sabine) Ameliorates Liver Damage and Reduces Hepatic Steatosis in Rats Fed with a High-fat Diet},
journal={Journal of Food and Nutrition Research},
volume={7},
number={2},
pages={132--140},
year={2019},
url={http://pubs.sciepub.com/jfnr/7/2/5},
issn={2333-1240},
abstract={Bioactive compounds, present in some foods, act enhancing the endogenous antioxidant system and are proposed as an effective strategy in preventing the changes induced by free radicals in some diseases, such as nonalcoholic fatty liver disease (NAFLD). There has been an increase in the number of studies carried out with the aim of finding natural antioxidant compounds present in fruits, mainly the native fruits of Brazil, because they contain a high content of these compounds. Ara?¨˘ (<i>Psidium cattleianum</i> Sabine) is a fruit that is rich in polyphenols and exhibits strong antioxidant, antiproliferative, and anti-inflammatory activities. Therefore, the present study investigated the effects of ara?¨˘ flour on oxidative stress, liver injury, and antioxidant defenses in high-fat diet-induced hepatic steatosis in rats. <i>In vitro</i> experiments showed that ara?¨˘ contains high concentrations of total polyphenols and exhibits strong antioxidant activity with no cytotoxicity. <i>In vivo</i> experiments indicated that the addition of ara?¨˘ to a high-fat diet inhibited the activities of alanine aminotransferase and aspartate enzymes, reduced macrovesicular steatosis, increased the paraoxonase activity, and increased the concentration of the total and reduced forms of glutathione. Therefore, our findings suggested the hepatoprotective role of ara?¨˘ against the progression of steatosis.},
doi={10.12691/jfnr-7-2-5}
publisher={Science and Education Publishing}
}