eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2019-12-23 7 12 845 850 10.12691/jfnr-7-12-5 JFNR20197125 article Cheng Liu 1 Leong-Perng Chan tinna_ling@mail.cnu.edu.tw, oleon24@yahoo.com.tw 2 3 Chia-Hua Liang tinna_ling@mail.cnu.edu.tw, oleon24@yahoo.com.tw 4 Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan This research unveils potential of the Rosa roxburghii formula drink for anti-oxidation, anti-aging, anti-inflammation, and the reduction of cancer risk. We recruited 40 high risk subjects (i.e., chronic smoker or drinker) and required them to have daily supplement of R. roxburghii formula drink over 12 weeks to investigate the long-term effect on health improvement. We discovered that the drink could increase mitochondrial activity (elevated nicotinamide adenine dinucleotide (NADH) level), alleviate inflammatory response by the reduction of tumor necrosis factor alpha (TNF-α) level, and diminish the expression of cancer biomarkers of 8-hydroxy-2’-deoxyguanosine (8-OHdG) and carcinoembryonic antigen (CEA). As a result, this is the first study to elucidate the synergistic effect of R.roxburghii and other five kinds of fruits on alleviation oxidative damages. http://pubs.sciepub.com/jfnr/7/12/5/jfnr-7-12-5.pdf Rosa roxburghii anti-aging anti-oxidation anti-inflammation drink