eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2019-11-23 7 11 794 800 10.12691/jfnr-7-11-6 JFNR20197116 article Osman H.F. 1 El-Mahdey A.A. 1 El-Sherbiny E.M. eelsherbiny71@yahoo.com 1 Radioisotopes Department, Nuclear Research Center, Atomic Energy Authority, Egypt The present investigation was designed to investigate the curative and protective effect of thyme as a natural product on thyroid and liver status in hypothyroid rats induced by propylthiouracil (PTU). The rats were classified into 4 groups; group I: control, group II, was intraperitoneally injected with 10 mg PTU/kg, for 21 days, group III was i.p. injected with 10 mg PTU/kg, for 21 days followed by 5% thyme for four weeks, and group IV was i.p. injected with 10 mg PTU/kg, for 21 days followed by 10% thyme for four weeks. Serum total cholesterol, HDL, LDL, triglycerides, AST, ALT, alkaline phosphatase, total protein, albumin, urea, creatinine, Na+, K+, GSH, GSH-px, SOD, MDA, TNF-, serum triiodothyronine (T3) and thyroxine (T4), were evaluated. Propylthiouracil injection resulted in a significant increase in total cholesterol, LDL, triglycerides, AST, ALT, ALP, urea and creatinine, MDA, and TNF-, whereas HDL, total protein, albumin, Na+, K+, GSH, GSH-px, SOD, T3 and T4 decreased significantly compared to control. The high dose of thyme extract (10%) ameliorated most of the harmful effect of PTU, this may be due to its contents of flavonoids, thymol, phenols and luteolin. http://pubs.sciepub.com/jfnr/7/11/6/jfnr-7-11-6.pdf Propylthiouracil Thymus vulgaris L liver functions lipid peroxides kidney functions thyroid functions rats