@article{jfnr20197116,
author={{H.F., Osman and A.A., El-Mahdey and E.M., El-Sherbiny},
title={Role of Thyme Extract against Some Biochemical Alterations Induced by Propylthiouracil in Male Rats},
journal={Journal of Food and Nutrition Research},
volume={7},
number={11},
pages={794--800},
year={2019},
url={http://pubs.sciepub.com/jfnr/7/11/6},
issn={2333-1240},
abstract={The present investigation was designed to investigate the curative and protective effect of thyme as a natural product on thyroid and liver status in hypothyroid rats induced by propylthiouracil (PTU). The rats were classified into 4 groups; group I: control, group II, was intraperitoneally injected with 10 mg PTU/kg, for 21 days, group III was i.p. injected with 10 mg PTU/kg, for 21 days followed by 5% thyme for four weeks, and group IV was i.p. injected with 10 mg PTU/kg, for 21 days followed by 10% thyme for four weeks. Serum total cholesterol, HDL, LDL, triglycerides, AST, ALT, alkaline phosphatase, total protein, albumin, urea, creatinine, Na<SUP>+</SUP>, K<SUP>+</SUP>, GSH, GSH-px, SOD, MDA, TNF-&#8733;, serum triiodothyronine (T<SUB>3</SUB>) and thyroxine (T<SUB>4</SUB>), were evaluated. Propylthiouracil injection resulted in a significant increase in total cholesterol, LDL, triglycerides, AST, ALT, ALP, urea and creatinine, MDA, and TNF-&#8733;, whereas HDL, total protein, albumin, Na+, K+, GSH, GSH-px, SOD, T<SUB>3</SUB> and T<SUB>4</SUB> decreased significantly compared to control. The high dose of thyme extract (10%) ameliorated most of the harmful effect of PTU, this may be due to its contents of flavonoids, thymol, phenols and luteolin.},
doi={10.12691/jfnr-7-11-6}
publisher={Science and Education Publishing}
}