eng Science and Education Publishing Journal of Food and Nutrition Research 2333-1240 2019-10-27 7 10 751 758 10.12691/jfnr-7-10-9 JFNR20197109 article Elcy Yaned 1 Astudillo -Muñoz elcyy.astudillom@unilibre.edu.co 1 2 Clara Helena González-Correa 2 Diana María 2 Muñoz -Pérez 2 2 Erika Martinez-Lopez 3 Daniel Camilo Aguirre-Acevedo 4 María Elena Alvarez Lopez 5 Department of Basic Sciences for Health, Research Group on nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, Colombia Department of Molecular Biology and Genomic, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico Academic Group of Clinical Epidemiology, Institute of Medical Research, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia Department of Basic Sciences for Health, Research Group on Regenerative Therapy, Universidad de Caldas, Manizales, Colombia People with obesity develop low-grade chronic inflammation, which is characterized by a high serum concentration of inflammatory markers (CRP, IL-6, TNF-α, and leptin), which predisposes the development of chronic diseases. These markers can be modulated by a diet; therefore, a research project was developed to determine the effect of a diet based on foods available in the Colombian Andean Region, containing anti-inflammatory properties in obese women. A controlled study was conducted with 30 women. For eight weeks the experimental group received a diet based on food rich in fiber, polyunsaturated fatty acids, vitamins and polyphenols. The experimental group reduced the serum concentrations of CRP (p = 0.005), IL-6 (p = 0.013) and leptin (p = 0.004), in comparison with the control group. Therefore, the findings suggest that a diet based on foods available in the Colombian Andean Region with anti-inflammatory nutrients reduces CRP, IL-6 and leptin in obese women. http://pubs.sciepub.com/jfnr/7/10/9/jfnr-7-10-9.pdf diet inflammation biomarkers obesity colombia