@article{jfnr2018697,
author={{Jingjing, Cai and Jing, Lv and Qianying, Guo and Boshi, Wang and Norstedt, Gunnar and Sederholm, Magnus and Peng, Liu},
title={Macronutrient Preload effect on Glycaemic Control and Pregnancy Outcome in Gestational Diabetes Mellitus},
journal={Journal of Food and Nutrition Research},
volume={6},
number={9},
pages={584--589},
year={2018},
url={http://pubs.sciepub.com/jfnr/6/9/7},
issn={2333-1240},
abstract={Objective: To investigate the effect of macronutrient preload treatment, MPT, on glycemic control and pregnancy outcome in gestational diabetes mellitus, GDM. Study Design: 40 patients with GDM were randomized to either MPT in addition to health education and dietary guidance (n=25) or health education and dietary guidance only (n=15). MPT was given three times/day, 30 minutes before regular meals and continued until term. Participants were subjected physical examination, laboratory analysis and pregnancy outcomes. Results: The time until the participant reached stable euglycemia was shorter in the preload group compared to controls (P&lt;0.05), in patients ¡Ý30 years old (1.3¡À0.55 versus 2.5¡À1.1 weeks, P&lt;0.05), in pre-gestational BMI&lt;24 kg/m<SUP>2</SUP> (1.3¡À0.58 versus 1.9¡À0.69 weeks, P&lt;0.05) and in pre-gestational BMI¡Ý24 kg/m<SUP>2</SUP> (1.2¡À0.44 versus 2.6¡À1.32 weeks, P&lt;0.05). The birth weight in the subgroup of BMI>24 kg/m<SUP>2</SUP><SUP> </SUP>was lower in the MTP group compared to the control group (3124¡À523g versus 3780.0¡À472g, P&lt;0.05). Increase of HbA1c ¡Ý5% was significantly lower after preload treatment. Conclusion; MPT can safely be used in patients with gestational diabetes mellitus for effective control of blood glucose. The significant reduction of birth weight in participants with pre-gestational BMI ¡Ý24kg/m<SUP>2</SUP><SUP> </SUP>indicates that preload can be used to control negative effects of hyperglycemia, with reduced risk for complications during delivery.},
doi={10.12691/jfnr-6-9-7}
publisher={Science and Education Publishing}
}